China (Mainland)
Prednisone CAS NO.1247-42-3
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- Product Details
Keywords
- Prednisone
- 1247-42-3
- Prednisone
Quick Details
- ProName: Prednisone
- CasNo: 1247-42-3
- Molecular Formula: C22H28O5
- Appearance: White to off-white (Solid)
- Application: Synthetic corticosteroid agent；effecti...
- PackAge: As per request
- Port: Shanghai
- ProductionCapacity: Metric Ton/Day
- Purity: 95%+
- Storage: Store in a tight container between 2-8...
- Transportation: by air or by sea
- LimitNum: 0 Metric Ton
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Details
Meprednisone is a glucocorticoid and a methylated derivative of prednisone. Target: Glucocorticoid Receptor Meprednisone is a glucocorticoid and a methylated derivative of prednisone. The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to altered interconversion between these steroids. An improved pharmacokinetic/dynamic receptor/gene-mediated model characterized the steroid receptor binding and induction of tyrosine aminotransferase activity after i.v. MPL sodium succinate (10 mg/kg). In contrast to previous in vitro studies, ketoconazole at maximally tolerated doses failed to antagonize the steroid receptor-mediated activity of MPL .